Fig. 2

Significant Correlations Between Protein Expression in MIS-C Patients and Continuous Clinical Variables. The 15 leading proteins of MIS-C on PICU Day 1 were compared with continuous clinical and demographic variables; significant correlations are shown (P < 0.05). Blue points are MIS-C patient measurements; the green-filled area represents the 25th–75th percentile protein expression range of healthy control subjects. The Spearman correlation Rho statistic (𝜌) and the significance value of the comparison are shown. (A-B) Plots demonstrating a positive correlation between hospital length of stay and LTA4H and PTN such that greater expression was associated with a greater length of stay, respectively; however, compared with healthy controls, LTA4H expression was greater in all MIS-C patients on Day 1 and PTN expression was lower in all MIS-C patients on Day 1. (C) Plots demonstrating a negative correlation between PPBP and PICU length of stay; lower expression was associated with a greater PICU length of stay. (D) Plot of EGF expression demonstrating a negative correlation with PIM2 mortality risk, such that greater expression was associated with lower PIM2 mortality risk.