The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis

Table 1 Demographics and clinical data

Variable	MIS-C Patients	SCNS Patients	P Value
Age (yrs), median (IQR)	12.0 (10.0–13.0)	12.5 (11.0-13.2)	0.617
Male sex, no. (%)	11 (91.7)	11 (91.7)	1.000
Weight (kg), median (IQR)	49.0 (36.7–57.5)	35.4 (31.8–48.7)	0.326
Clinical Measures, median (IQR)
PRISM III Score	5.5 (2.8–7.3)	6.5 (2.2–13.8)	0.663
PIM2 Mortality Risk	1.2 (1.0-4.4)	-3.4 (-4.3–2.8)	< 0.001
dPELOD Initial	1 (0.0–3.0)	10.5 (0.0–12.0)	0.063
sPELOD Score Highest	2.5 (0.8–3.2)	12.0 (11.0-12.5)	< 0.001
GCS Admission	15.0 (15.0–15.0)	14.0 (7.0–15.0)	0.007
Source of Infection, no. (%)
Respiratory	12 (100.0)	8 (66.7)	0.093
Cardiovascular	0 (0)	2 (16.7)	0.478
Gastrointestinal	0 (0)	1 (8.3)	1.000
Wound	0 (0)	1 (8.3)	1.000
Pathogen Type, no. (%)
Bacteria - Gram positive	0 (0)	2 (16.7)	0.478
Bacteria - Gram negative	0 (0)	6 (50.0)	0.014
Viral¹/Bacteria Gram positive	0 (0)	1 (8.3)	1.000
Viral postive¹	0 (0)	3 (25.0)	0.217
SARS-CoV-2 positive	12 (100)	0 (0)	< 0.001
Ventilation, no. (%)
Invasive Ventilation	2 (16.7)	6 (50.0)	0.192
Non-Invasive Ventilation	2 (16.7)	2 (16.7)	1.000
Hemodynamic Support, no. (%)
Inotrope/Vasopressors	8 (66.7)	10 (83.3)	0.640
Outcomes, median (IQR)
Alive, no. (%)	12 (100.0)	12 (100.0)	1.000
PICU length of stay	5.5 (2.0-7.5)	5.5 (2.8–10.2)	0.706
Hospital length of stay	8.0 (5.8–10.5)	12.5 (9.5–16.8)	0.040

Note Continuous variables compared with Mann-Whitney U Test. Binary variables compared with Fisher Exact Test. ¹SARS-CoV-2 negative viral illness

ISSN: 1528-3658