Table 2 Importance of the 15 biomarkers in distinguishing MIS-C from SCNS
Rank | Assay | MIS-C Patients | SCNS Patients | pValue | ROC AUC | F1 | Feature Importance |
|---|---|---|---|---|---|---|---|
1 | MRPL58 | 0.7 (0.5–0.8) | 1.0 (1.0–2.0) | 0.00003 | 1.00 | 0.82 | 8.89 |
2 | LTA4H | 0.8 (0.3-1.0) | 0.1 (0.0-0.1) | 0.00004 | 1.00 | 0.80 | 8.75 |
3 | BTLA | 0.4 (0.2–0.6) | 1.0 (1.0–1.0) | 0.00002 | 1.00 | 0.98 | 8.58 |
4 | C3 | 1.0 (0.6-1.0) | 0.2 (0.2–0.2) | 0.00003 | 1.00 | 0.85 | 8.50 |
5 | PDGFA | 3.0 (1.8-4.0) | 0.5 (0.4–0.5) | 0.00003 | 1.00 | 0.84 | 8.43 |
6 | F10 | 2.0 (2.0–2.0) | 0.6 (0.5–0.8) | 0.00002 | 1.00 | 0.89 | 8.38 |
7 | ANGPT1 | 4.0 (2.0-4.2) | 0.5 (0.4–0.6) | 0.00003 | 1.00 | 0.94 | 8.37 |
8 | CREBZF | 0.1 (0.0-0.2) | 1.0 (0.8-1.0) | 0.00004 | 1.00 | 0.96 | 8.33 |
9 | PPBP | 3.0 (2.0-4.2) | 0.2 (0.1–0.3) | 0.00004 | 1.00 | 0.90 | 8.25 |
10 | PTN | 0.2 (0.1–0.5) | 1.0 (1.0-2.2) | 0.00004 | 0.99 | 0.90 | 5.43 |
11 | BDNF | 1.0 (0.9-2.0) | 0.1 (0.1–0.2) | 0.00004 | 0.99 | 0.89 | 5.31 |
12 | SERPINI1 | 1.0 (0.9-1.0) | 0.4 (0.3–0.6) | 0.00005 | 0.99 | 0.91 | 3.95 |
13 | BMP4 | 0.0 (0.0–0.0) | 0.1 (0.1–0.1) | 0.00006 | 0.99 | 0.94 | 3.54 |
14 | EGF | 6.0 (2.8–11.0) | 0.4 (0.2–0.5) | 0.00009 | 0.97 | 0.91 | 3.28 |
15 | LYSMD3 | 0.6 (0.5–0.8) | 0.1 (0.1–0.3) | 0.00009 | 0.97 | 0.88 | 2.02 |