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Fig. 7 | Molecular Medicine

Fig. 7

From: Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

Fig. 7

Combination of G-Rh2 with DCA reversed the tumor’s biometabolic behavior and reduced DCA dosage. (A) Viability of human A549 cells assessed by CCK8 assays after 24-hours treatment with different concentrations of G-Rh2 and DCA. (B, C) Colony formation assay demonstrating A549 cell proliferation following treatment with G-Rh2 and DCA. (D, E) Transwell assays measuring A549 cell migration ability after 24-hours treatment with G-Rh2 and DCA. (F, G) Wound healing assays indicating the inhibitory effect of G-Rh2 on the invasion ability of A549 cells after 24-hours treatment with G-Rh2 and DCA. (H-I) Flow cytometry analysis showing A549 cell apoptosis after treatment with G-Rh2 and DCA. (J) Proposed mechanism illustrating G-Rh2-induced changes in glucose metabolism in NSCLC cells. Data are expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001 vs. the control group

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Molecular Medicine

ISSN: 1528-3658