Fig. 7
From: STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
Targeting STK16 Inhibited Colorectal Cancer Proliferation In Vivo. A. Representative tumor images shown. B. Drawing tumor growth curve of the three groups (n = 5). C. Statistical analysis of tumor weight. D. Kaplan-Meier Plot was drawn for the three groups (n = 12). E, F. IHC (E) and IB (F) assays to detect the expression level of identified proteins. G. Representative tumor images shown. H. Drawing tumor growth curve of the two groups (n = 5). I. Statistical analysis of tumor weight. J. Kaplan-Meier Plot was drawn for the two groups (n = 13 for DMSO and n = 12 for STK16-IN-1). K, L. IHC (K) and IB (L) assays to detect the expression level of identified proteins. M. The working model: STK16 inhibits the ubiquitin-proteasome pathway degradation of c-MYC by phosphorylating c-MYC at S452, contributing to colorectal cancer progress