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Page 34 of 37

  1. Gender dimorphisms exist in the pathogenesis of a variety of cardiovascular, cardiopulmonary, neurodegenerative, and endocrine disorders. Estrogens exert immense influence on myocardial remodeling following is...

    Authors: Rinki Ray, Nathan M. Novotny, Paul R. Crisostomo, Tim Lahm, Aaron Abarbanell and Daniel R. Meldrum
    Citation: Molecular Medicine 2008 14:140070493
    Content type: Review Article Published on:

  2. Multiple lines of evidence suggest that inhibition of Type I Interferons, including IFN-α, may provide a therapeutic benefit for autoimmune diseases. Using a chemical genomics approach integrated with cellular...

    Authors: Bo Chen, Qin Zong, Ricardo Cibotti, Chad Morris, Juana Castaneda, Brian Naiman, Derong Liu, Anna Glodek, Gary P. Sims, Ronald Herbst, Stephen K. Horrigan, Peter A. Kiener, Dan Soppet, Anthony J. Coyle and Laurent Audoly
    Citation: Molecular Medicine 2008 14:140070374
    Content type: Research Article Published on:

  3. While foreign pathogens and their products have long been known to activate the innate immune system, the recent recognition of a group of endogenous molecules that serve a similar function has provided a fram...

    Authors: John R. Klune, Rajeev Dhupar, Jon Cardinal, Timothy R. Billiar and Allan Tsung
    Citation: Molecular Medicine 2008 14:140070476
    Content type: Review Article Published on:

  4. We previously have communicated our discovery that the amyloid associated with calcifying epithelial odontogenic tumors is composed of N-terminal fragments of the structurally novel odontogenic ameloblast-asso...

    Authors: Daniel P. Kestler, James S. Foster, Sallie D. Macy, Charles L. Murphy, Deborah T. Weiss and Alan Solomon
    Citation: Molecular Medicine 2008 14:1405318
    Content type: Research Article Published on:

  5. Over the past two decades, inflammation has been recognized as a major driver in the pathogenesis of several common diseases, including atherosclerosis, diabetes, cancer, and asthma. Over the same period, ther...

    Authors: Carl Nathan
    Citation: Molecular Medicine 2008 14:140070485
    Content type: Review Article Published on:

  6. Low gene expression of folylpolyglutamate synthase (FPGS) in colorectal mucosa correlates with low folate levels and poor survival of colorectal cancer (CRC) patients. Because gene-specific hypermethylation is af...

    Authors: Yvonne Wettergren, Elisabeth Odin, Staffan Nilsson, Göran Carlsson and Bengt Gustavsson
    Citation: Molecular Medicine 2008 14:140070412
    Content type: Research Article Published on:

  7. Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East. The zinc-deficient patients ha...

    Authors: Ananda S. Prasad
    Citation: Molecular Medicine 2008 14:1405353
    Content type: Review Article Published on:

  8. The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer’s disease (AD)-relevant cortical and limbic structures, deficits in spatial reference memory, and progression of ...

    Authors: Rita M. Ramalho, Ricardo J. S. Viana, Rui E. Castro, Clifford J. Steer, Walter C. Low and Cecília M. P. Rodrigues
    Citation: Molecular Medicine 2008 14:1405309
    Content type: Research Article Published on:

  10. In spite of protective ventilatory strategies, Acute Lung Injury (ALI) remains associated with high morbidity and mortality. One reason for the lack of therapeutic options might be that ALI is a co-morbid even...

    Authors: Mario Perl, Joanne Lomas-Neira, Chun-Shiang Chung and Alfred Ayala
    Citation: Molecular Medicine 2008 14:140070465
    Content type: Review Article Published on:

  11. Developing effective treatments for neurodegenerative diseases is one of the greatest medical challenges of the 21st century. Although many of these clinical entities have been recognized for more than a hundr...

    Authors: G. Brent Irvine, Omar M. El-Agnaf, Ganesh M. Shankar and Dominic M. Walsh
    Citation: Molecular Medicine 2008 14:140070451
    Content type: Review Article Published on:

  12. Septic shock is the most severe form of sepsis. It is widely accepted that cytokines play pivotal roles in the pathophysiology of septic shock. We reported previously that continuous hemodiafiltration (CHDF) u...

    Authors: Taka-aki Nakada, Shigeto Oda, Ken-ichi Matsuda, Tomohito Sadahiro, Masataka Nakamura, Ryuzo Abe and Hiroyuki Hirasawa
    Citation: Molecular Medicine 2008 14:1405257
    Content type: Research Article Published on:

  13. Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that IR is associated with a s...

    Authors: Herbert Tilg and Alexander R. Moschen
    Citation: Molecular Medicine 2008 14:14030222
    Content type: Review Article Published on:

  14. Trauma-hemorrhage leads to prolonged immune suppression, sepsis, and multiple organ failure. The condition affects all compartments of the immune system, and extensive studies have been carried out elucidating...

    Authors: Raghavan Raju, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2008 14:14030213
    Content type: Review Article Published on:

  15. This review describes the current knowledge of the pathogenesis of acute Lyme neuroborreliosis (LNB), from invasion to inflammation of the central nervous system. Borrelia burgdorferi (B.b.) enters the host throu...

    Authors: Tobias A. Rupprecht, Uwe Koedel, Volker Fingerle and Hans-Walter Pfister
    Citation: Molecular Medicine 2008 14:14030205
    Content type: Review Article Published on:

  16. It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can syn...

    Authors: Michael A. Flierl, Daniel Rittirsch, Markus Huber-Lang, J. Vidya Sarma and Peter A. Ward
    Citation: Molecular Medicine 2008 14:14030204
    Content type: Review Article Published on:

  17. Presenilin (PS) mutations enhance the production of the Aβ42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Aβ42 species is preferentially produced has not been e...

    Authors: Gregory D. Van Vickle, Chera L. Esh, Tyler A. Kokjohn, R. Lyle Patton, Walter M. Kalback, Dean C. Luehrs, Thomas G. Beach, Amanda J. Newel, Francisco Lopera, Bernardino Ghetti, Ruben Vidal, Eduardo M. Castaño and Alex E. Roher
    Citation: Molecular Medicine 2008 14:14030184
    Content type: Review Article Published on:

  18. α-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair, ...

    Authors: Renata Alleva, Marco Tomasetti, Davide Sartini, Monica Emanuelli, Emanuele Nasole, Ferruccio Di Donato, Battista Borghi, Lory Santarelli and Jiri Neuzil
    Citation: Molecular Medicine 2008 14:14030175
    Content type: Research Article Published on:

  19. Fanconi anemia (FA) predisposes to hematopoietic failure, birth defects, leukemia, and squamous cell carcinoma of the head and neck (HNSCC) and cervix. The FA/BRCA pathway includes 8 members of a core complex ...

    Authors: Kazuhiko Yamamoto, Abdallah Nihrane, Jason Aglipay, Juan Sironi, Steven Arkin, Jeffrey M. Lipton, Toru Ouchi and Johnson M. Liu
    Citation: Molecular Medicine 2008 14:14030167
    Content type: Research Article Published on:

  20. Meniscal tears are attributed to either trauma or degeneration processes. Clinical data suggest that meniscal degeneration (MD) is associated with knee osteoarthritis; however, the molecular events underpinnin...

    Authors: Dionysios J. Papachristou, Eugenia Papadakou, Efthimia K. Basdra, Panagiotis Baltopoulos, Elias Panagiotopoulos and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2008 14:14030160
    Content type: Research Article Published on:

  21. In osteoarthritis (OA), cartilage destruction is associated not only with an Imbalance of anabolic and catabolic processes but also with alterations of the cytoskeletal organization in chondrocytes, although t...

    Authors: Helga Joos, Wolfgang Albrecht, Stefan Laufer, Heiko Reichel and Rolf E. Brenner
    Citation: Molecular Medicine 2008 14:14030150
    Content type: Research Article Published on:

  22. Nitric oxide (NO) signaling is important for the regulation of hematopoiesis. However, the role of Individual NO synthase (NOS) isoforms is unclear. Our results indicate that the neuronal NOS isoform (nNOS) re...

    Authors: Peter Krasnov, Tatyana Michurina, Michael A. Packer, Yuri Stasiv, Naoki Nakaya, Kateri A. Moore, Kenneth E. Drazan and Grigori Enikolopov
    Citation: Molecular Medicine 2008 14:14030141
    Content type: Research Article Published on:

  23. The mechanism mediating the development of ventricular arrhythmia (VA) after acute myocardial Infarction (AMI) Is still uncertain. Thrombin receptor (TR) activation has been proven to be arrhythmogenic in many...

    Authors: Lilong Tang, Chunyu Deng, Ming Long, Anli Tang, Shulin Wu, Yugang Dong, Louis D. Saravolatz and Julius M. Gardin
    Citation: Molecular Medicine 2008 14:14030131
    Content type: Research Article Published on:

  24. Macrophage migration inhibitory factor (MIF), a proinflammatory mediator, has been shown to be elevated following heart surgery in adults and may be associated with several postoperative complications, includi...

    Authors: Sanah Merchant, Sumekala Nadaraj, Devyani Chowdhury, Vincent A. Parnell, Cristina Sison, Edmund J. Miller and Kaie Ojamaa
    Citation: Molecular Medicine 2008 14:14030124
    Content type: Research Article Published on:

  25. Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls i...

    Authors: Alexander Choukèr, Manfred Thiel, Dmitriy Lukashev, Jerrold M. Ward, Ines Kaufmann, Sergey Apasov, Michail V. Sitkovsky and Akio Ohta
    Citation: Molecular Medicine 2008 14:14030116
    Content type: Research Article Published on:

  26. Chronic kidney disease (CKD) is associated with inflammation and malnutrition and carries a markedly increased risk of cardiovascular disease (CVD). High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nucle...

    Authors: Annette Bruchfeld, Abdul Rashid Qureshi, Bengt Lindholm, Peter Barany, LiHong Yang, Peter Stenvinkel and Kevin J. Tracey
    Citation: Molecular Medicine 2008 14:14030109
    Content type: Research Article Published on:

  27. Previous phenotyping of glucose homeostasis and insulin secretion in a mouse model of hereditary hemochromatosis (Hfe−/−) and iron overload suggested mitochondrial dysfunction. Mitochondria from Hfe−/− mouse live...

    Authors: Hani A. Jouihan, Paul A. Cobine, Robert C. Cooksey, Emily A. Hoagland, Sihem Boudina, E. Dale Abel, Dennis R. Winge and Donald A. McClain
    Citation: Molecular Medicine 2008 14:14030098
    Content type: Research Article Published on:

  28. Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM) (coma). Red cells of children with severe malaria-a...

    Authors: Boaz O. Owuor, Collins O. Odhiambo, Walter O. Otieno, Christine Adhiambo, Dominic W. Makawiti and José A. Stoute
    Citation: Molecular Medicine 2008 14:14030089
    Content type: Research Article Published on:

  29. Endothelial progenitor cells (EPCs) have been shown to be involved in vascular regeneration and angiogenesis in experimental diabetes. Because insulin therapy mobilizes circulating progenitor cells, we studied...

    Authors: Per M. Humpert, Zdenka Djuric, Ulf Zeuge, Dimitrios Oikonomou, Yuri Seregin, Klaus Laine, Volker Eckstein, Peter P. Nawroth and Angelika Bierhaus
    Citation: Molecular Medicine 2008 14:1405301
    Content type: Research Article Published on:

  30. Isolated growth hormone deficiency (IGHD) may be of genetic origin. One of the few genes involved in that condition encodes the growth hormone releasing hormone receptor (GHRHR) that, through its ligand (GHRH)...

    Authors: Latifa Hilal, Yassir Hajaji, Marie-Pierre Vie-Luton, Zeina Ajaltouni, Bouchra Benazzouz, Maha Chana, Adelmajid Chraïbi, Abdelkrim Kadiri, Serge Amselem and Marie-Laure Sobrier
    Citation: Molecular Medicine 2008 14:1405286
    Content type: Research Article Published on:

  31. The development of immunosuppression during polymicrobial sepsis is associated with the failure of dendritic cells (DC) to promote the polarization of T helper (Th) cells toward a protective Th1 type. The aim ...

    Authors: Stefanie B. Flohé, Hemant Agrawal, Sascha Flohé, Meenakshi Rani, Jörg M. Bangen and F. Ulrich Schade
    Citation: Molecular Medicine 2008 14:1405247
    Content type: Research Article Published on:

  33. Recent evidence suggests that additional risk loci for RA are present in the major histocompatibility complex (MHC), independent of the class II HLA-DRB1 locus. We have now tested a total of 1,769 SNPs across ...

    Authors: Hye-Soon Lee, Annette T. Lee, Lindsey A. Criswell, Michael F. Seldin, Christopher I. Amos, John P. Carulli, Cristina Navarrete, Elaine F. Remmers, Daniel L. Kastner, Robert M. Plenge, Wentian Li and Peter K. Gregersen
    Citation: Molecular Medicine 2008 14:1405293
    Content type: Research Article Published on:

  34. Loss of kidney graft function with tubular atrophy (TA) and interstitial fibrosis (IF) causes most kidney allograft losses. We aimed to identify the molecular pathways involved in IF/TA progression. Kidney bio...

    Authors: Daniel G. Maluf, Valeria R. Mas, Kellie J. Archer, Kenneth Yanek, Eric M. Gibney, Anne L. King, Adrian Cotterell, Robert A. Fisher and Marc P. Posner
    Citation: Molecular Medicine 2008 14:1405276
    Content type: Research Article Published on:

  35. Septic cardiomyopathy is a well-described complication of severe sepsis and septic shock. However, the interplay of its underlying mechanisms remains enigmatic. Consequently, we constantly add to our pathophys...

    Authors: Michael A. Flierl, Daniel Rittirsch, Markus S. Huber-Lang, J. Vidya Sarma and Peter A. Ward
    Citation: Molecular Medicine 2008 14:1405327
    Content type: Review Article Published on:

  36. Toll-like receptor 4 (TLR4) is an important pathogen recognition receptor that recognizes mainly lipopolysaccharide (LPS) of Gram-negative bacteria, but also structures from fungal and mycobacterial pathogens,...

    Authors: Bart Ferwerda, Matthew B. B. McCall, Karlijn Verheijen, Bart-Jan Kullberg, André J. A. M. van der Ven, Jos W. M. Van der Meer and Mihai G. Netea
    Citation: Molecular Medicine 2008 14:1405346
    Content type: Review Article Published on:

  37. Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases (RTKs) play an important role in the enhanced prolife...

    Authors: Linda Yu, Katrin Saile, Carol D. Swartz, Hong He, Xiaolin Zheng, Grace E. Kissling, Xudong Di, Shantelle Lucas, Stanley J. Robboy and Darlene Dixon
    Citation: Molecular Medicine 2008 14:1405264
    Content type: Research Article Published on:

  38. We have recently demonstrated that oxidants can activate monocytes via an action on Toll-like receptor (TLR) 2; however, it is unclear what functional consequence this has on immune surveillance for Gram-negat...

    Authors: Mark J. Paul-Clark, Rosalinda Sorrentino, Lucy K. Bailey, Shiranee Sriskandan and Jane A. Mitchell
    Citation: Molecular Medicine 2008 14:1405238
    Content type: Research Article Published on:

  39. Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competi...

    Authors: Husnain K. Haider, Ibrahim Elmadbouh, Michel Jean-Baptiste and Muhammad Ashraf
    Citation: Molecular Medicine 2008 14:14010079
    Content type: Review Article Published on:

  40. Septic syndromes represent a major although largely underrecognized healthcare problem worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis deeply perturbs immune homeostasis ...

    Authors: Guillaume Monneret, Fabienne Venet, Alexandre Pachot and Alain Lepape
    Citation: Molecular Medicine 2008 14:14010064
    Content type: Review Article Published on:

  41. Interleukin-1 (IL-1) is a potent regulator of cell proliferation, inflammation, and contraction of cardiovascular cells. It has been proposed that the IL-1/IL-1ra (IL-1 receptor antagonist) ratio influences th...

    Authors: Elena Westphal, Susanne Rohrbach, Michael Buerke, Hagen Behr, Dorothea Darmer, Rolf-Edgar Silber, Karl Werdan and Harald Loppnow
    Citation: Molecular Medicine 2008 14:14010055
    Content type: Research Article Published on:

  42. Early detection and accurate staging of gastrointestinal (GI) cancers are difficult. The aim of this study was to evaluate whether telomerase activity (TA) in exfoliated/disseminated epithelial cells could be ...

    Authors: Inna L. Botchkina, David E. Rivadeneira, Kevin Watkins, Martin S. Karpeh and Galina I. Botchkina
    Citation: Molecular Medicine 2008 14:14010045
    Content type: Research Article Published on:

  43. We compared gene expression in blood neutrophils (polymorphonuclear leukocytes, or PMNs) collected from healthy subjects with those of cystic fibrosis (CF) patients devoid of bacterial colonization. Macroarray...

    Authors: Minou Adib-Conquy, Thierry Pedron, Anne-France Petit-Bertron, Olivier Tabary, Harriet Corvol, Jacky Jacquot, Annick Clément and Jean-Marc Cavaillon
    Citation: Molecular Medicine 2008 14:14010036
    Content type: Research Article Published on:

  44. The antithrombotic effect of angiotensin(Ang)-(1-7) has been reported, but the mechanism of this effect is not known. We investigated the participation of platelets and receptor Mas-related mechanisms in this ...

    Authors: Rodrigo Araújo Fraga-Silva, Sergio Veloso Brant Pinheiro, Andrey Christian Costa Gonçalves, Nathalia Alenina, Michael Bader and Robson Augusto Souza Santos
    Citation: Molecular Medicine 2008 14:14010028
    Content type: Research Article Published on:

  45. Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in adults in the developed world. Despite significant advances in the treatment of cancer, CLL remains incurable. The main feature of the ...

    Authors: Imke Bokelmann and Ulrich Mahlknecht
    Citation: Molecular Medicine 2008 14:14010020
    Content type: Research Article Published on:

  46. Hepatic homeostasis is essential for survival in critically ill and burned patients. Insulin administration improves survival and decreases infections in these patients. To determine the molecular mechanisms, ...

    Authors: Marc G. Jeschke, Dagmar Klein, Wolfgang E. Thasler, Ulrich Bolder, Hans-Jürgen Schlitt, Karl-Walter Jauch and Thomas S. Weiss
    Citation: Molecular Medicine 2008 14:14010011
    Content type: Research Article Published on:

  47. Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 µg/mL in culture for up ...

    Authors: Gengyun Wen, Gloria M. Calaf, Michael A. Partridge, Carlos Echiburú-Chau, Yongliang Zhao, Sarah Huang, Yunfei Chai, Bingyan Li, Burong Hu and Tom K. Hei
    Citation: Molecular Medicine 2008 14:14010002
    Content type: Research Article Published on:

  48. Authors: Margot Gallowitsch-Puerta
    Citation: Molecular Medicine 2008 14:BF03402219
    Content type: EditorialNotes Published on:

  49. The identification of specific biomarkers provides opportunities to develop early diagnostic parameters, monitor disease progression, and test drug efficiency in clinical trials. We previously demonstrated tha...

    Authors: Bárbara Macedo, Ana Rita Batista, José Barbas do Amaral and Maria João Saraiva
    Citation: Molecular Medicine 2007 13:130110584
    Content type: Research Article Published on:

  50. FOXO forkhead transcription factors play an important role in controlling lymphocyte activation and proliferation. To evaluate the possibility that FOXO transcriptional expression is dysregulated in systemic l...

    Authors: Chia-Chen Kuo and Shih-Chang Lin
    Citation: Molecular Medicine 2007 13:130110561
    Content type: Research Article Published on:
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ISSN: 1528-3658