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  2. A number of Lys-Pro-containing short peptides have been described as possessing a variety of biological activities in vitro. Because of limited metabolic stability, however, their efficacy in vivo is uncertain...

    Authors: Silvia Bertuglia, Hideo Ichimura, Gianluca Fossati, Kaushik Parthasarathi, Flavio Leoni, Daniela Modena, Piero Cremonesi, Jahar Bhattacharya and Paolo Mascagni
    Citation: Molecular Medicine 2007 13:130110615
    Content type: Research Article Published on:

  3. The induction of proinflammatory cytokines in stressed myocardium is considered an innate immune response, but the role of β-adrenergic signaling in this proinflammatory response and the mechanisms of cardiopr...

    Authors: Susanne Rohrbach, Stefan Engelhardt, Martin J. Lohse, Karl Werdan, Juergen Holtz and Ursula Muller-Werdan
    Citation: Molecular Medicine 2007 13:130110605
    Content type: Research Article Published on:

  4. Sepsis, which is the product of a poorly controlled inflammatory response, is a major health problem. Adequate therapies for sepsis are unavailable, and patient care is mainly supportive. Statins, widely used ...

    Authors: Tiffany Frey and Antonio De Maio
    Citation: Molecular Medicine 2007 13:130110592
    Content type: Research Article Published on:

  5. Pregnancy-induced hypertension (PIH), also known as preeclampsia, Is one of the major causes of maternal and fetal death. While the precise cause of PIH is not known, aberrant cytokine production and placenta ...

    Authors: Oonagh Dowling, Burton Rochelson, Kathleen Way, Yousef Al-Abed and Christine N. Metz
    Citation: Molecular Medicine 2007 13:130110576
    Content type: Research Article Published on:

  6. Stathmin (Oncoprotein18), a signal transduction regulatory factor, plays an Important role In cell division and malignant tumor development. Stathmin is a ubiquitous intracellular phosphoprotein that is overexpre...

    Authors: Rui Wang, Ke Dong, Fang Lin, Xi Wang, Ping Gao, San-Hua Wei, Shi-Yin Cheng and Hui-Zhong Zhang
    Citation: Molecular Medicine 2007 13:130110567
    Content type: Research Article Published on:

  7. Clearance of apoptotic cells is crucial to maintain cellular function under normal and pathological conditions. We have recently shown that administration of immature dendritic cell-derived exosomes to septic ...

    Authors: Michael Miksa, Dhruv Amin, Rongqian Wu, Weifeng Dong, Thanjavur S. Ravikumar and Ping Wang
    Citation: Molecular Medicine 2007 13:130110553
    Content type: Research Article Published on:

  8. Extracellular matrix (ECM) molecules and growth factors, such as fibroblast growth factor (FGF), play a crucial role in Alzheimer’s disease (AD). The purpose of this investigation was to determine whether phen...

    Authors: Catia Bellucci, Cinzia Lilli, Tiziano Baroni, Lucilla Parnetti, Sandro Sorbi, Carla Emiliani, Eleonora Lumare, Paolo Calabresi, Stefania Balloni and Maria Bodo
    Citation: Molecular Medicine 2007 13:1309542
    Content type: Research Article Published on:

  10. Fulminant hepatitis in Asian pregnant women is generally caused by hepatitis E virus infection, and extremely high mortality is most common in them. Decreased cell-mediated immunity is considered a major cause...

    Authors: Bhupesh K. Prusty, Suresh Hedau, Ajay Singh, Premasis Kar and Bhudev C. Das
    Citation: Molecular Medicine 2007 13:1309518
    Content type: Research Article Published on:

  11. Previous studies have shown that erythropoietin (EPO) has protective effects against ischemia/reperfusion (I/R) injury in several tissues. The aim of this study was to determine whether EPO could prevent intes...

    Authors: Ensari Guneli, Zahide Cavdar, Huray Islekel, Sulen Sarioglu, Serhat Erbayraktar, Muge Kiray, Selman Sokmen, Osman Yilmaz and Necati Gokmen
    Citation: Molecular Medicine 2007 13:1309509
    Content type: Research Article Published on:

  12. We have conducted longitudinal studies focused on the expression profiles of signaling pathways and gene networks In children with septic shock. Genome-level expression profiles were generated from whole blood...

    Authors: Thomas P. Shanley, Natalie Cvijanovich, Richard Lin, Geoffrey L. Allen, Neal J. Thomas, Allan Doctor, Meena Kalyanaraman, Nancy M. Tofil, Scott Penfil, Marie Monaco, Kelli Odoms, Michael Barnes, Bhuvaneswari Sakthivel, Bruce J. Aronow and Hector R. Wong
    Citation: Molecular Medicine 2007 13:1309495
    Content type: Research Article Published on:

  13. Downregulation of vascular endothelial constitutive nitric oxide synthase (ecNOS) contributes to the vascular hyporesponsiveness in sepsis. Although coadministration of the potent vasodilatory peptide adrenome...

    Authors: Mian Zhou, Subir R. Maitra and Ping Wang
    Citation: Molecular Medicine 2007 13:1309488
    Content type: Research Article Published on:

  14. The modulation of angiogenic processes in matrices is of great interest in tissue engineering. We assessed the angiogenic effects of fibrin-immobilized VEGF and bFGF in an arteriovenous loop (AVL) model in 22 ...

    Authors: Andreas Arkudas, Jimmy Tjiawi, Oliver Bleiziffer, Lucia Grabinger, Elias Polykandriotis, Justus P. Beier, Michael Stürzl, Raymund E. Horch and Ulrich Kneser
    Citation: Molecular Medicine 2007 13:1309480
    Content type: Research Article Published on:

  15. A deficiency of arylsulfatase A (ASA) causes metachromatic leukodystrophy (MLD), a lysosomal storage disorder characterized by accumulation of sulfatide, a severe neurological phenotype and early death. The ef...

    Authors: Ulrich Matzner, Frank Matthes, Eva Herbst, Renate Lüllmann-Rauch, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Cecilia Weigelt, Carl Eistrup, Jens Fogh and Volkmar Gieselmann
    Citation: Molecular Medicine 2007 13:1309471
    Content type: Research Article Published on:

  16. The muscle wasting associated with long-term intensive care unit (ICU) treatment has a negative effect on muscle function resulting in prolonged periods of rehabilitation and a decreased quality of life. To id...

    Authors: Jenny Nordquist, Anna-Stina Höglund, Holly Norman, Xiaorui Tang, Barry Dworkin and Lars Larsson
    Citation: Molecular Medicine 2007 13:1309461
    Content type: Research Article Published on:

  17. A recent study in the North American White population has documented the association of a common STAT4 haplotype (tagged by rs7574865) with risk for rheumatoid arthritis (RA) and systemic lupus erythematosus. ...

    Authors: Hye-Soon Lee, Elaine F. Remmers, Julie M. Le, Daniel L. Kastner, Sang-Cheol Bae and Peter K. Gregersen
    Citation: Molecular Medicine 2007 13:1309455
    Content type: Research Article Published on:

  18. Diallyl sulfide (DAS), an active component of garlic, possesses strong anti-neoplastic properties against various forms of cancer. In the present study, we have evaluated chemo-preventive effects of liposomize...

    Authors: Arif Khan, Yogeshwer Shukla, Neetu Kalra, Maroof Alam, Manzoor Gatoo Ahmad, Seema Rashid Hakim and Mohammad Owais
    Citation: Molecular Medicine 2007 13:130070443
    Content type: Proceedings Published on:

  19. Apert syndrome (AS), a severe form of craniosynostosis, is caused by dominant gain-of-function mutations in FGFR2. Because the periosteum contribution to AS cranial pathophysiology is unknown, we tested the os...

    Authors: Roberto D. Fanganiello, Andréa L. Sertié, Eduardo M. Reis, Erika Yeh, Nélio A. J. Oliveira, Daniela F. Bueno, Irina Kerkis, Nivaldo Alonso, Sérgio Cavalheiro, Hamilton Matsushita, Renato Freitas, Sergio Verjovski-Almeida and Maria Rita Passos-Bueno
    Citation: Molecular Medicine 2007 13:130070422
    Content type: Proceedings Published on:

  20. We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme Involved In the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measure...

    Authors: Davide Sartini, Andrea Santarelli, Valentina Rossi, Gaia Goteri, Corrado Rubini, Domenico Ciavarella, Lorenzo Lo Muzio and Monica Emanuelli
    Citation: Molecular Medicine 2007 13:130070415
    Content type: Proceedings Published on:

  21. A significant portion of patients with 22q11 deletion syndrome (22q11DS) develop psychiatric disorders, including schizophrenia and other psychotic and affective symptoms, and the responsible gene/s are assume...

    Authors: Birgit H. Funke, Todd Lencz, Christine T. Finn, Pamela DeRosse, G. David Poznik, Alex M. Plocik, John Kane, John Rogus, Anil K. Malhotra and Raju Kucherlapati
    Citation: Molecular Medicine 2007 13:130070407
    Content type: Proceedings Published on:

  22. Zinc transporter LIV-1 (SLC39A6) is estrogen regulated and present in increased amounts in estrogen receptor-positive breast cancer as well as in tumors that spread to the lymph nodes. The LIV-1 subfamily of Z...

    Authors: Kathryn M. Taylor, Helen E. Morgan, Kathryn Smart, Normawati M. Zahari, Sara Pumford, Ian O. Ellis, John F. R. Robertson and Robert I. Nicholson
    Citation: Molecular Medicine 2007 13:130070396
    Content type: Proceedings Published on:

  23. Carotid artery stenosis (CS) is a well-established risk factor for stroke. Increased proinflammatory chemokines, enhanced metallothionein (MT), and altered metal homeostasis may play roles in atherosclerosis p...

    Authors: Robertina Giacconi, Elisa Muti, Marco Malavolta, Catia Cipriano, Laura Costarelli, Gianni Bernardini, Nazzarena Gasparini, Erminia Mariani, Vittorio Saba, Gianfranco Boccoli and Eugenio Mocchegiani
    Citation: Molecular Medicine 2007 13:130070388
    Content type: Proceedings Published on:

  24. Ischemic stroke is one of the most pervasive life-threatening neurological conditions for which there currently exists limited therapeutic intervention beyond prevention. As calcium-focused neuroprotective str...

    Authors: Sherri L. Galasso and Richard H. Dyck
    Citation: Molecular Medicine 2007 13:130070380
    Content type: Proceedings Published on:

  27. An individual’s zinc status has a significant impact on the immune system, and zinc deficiency, as well as supplementation, modulates immune function. To investigate the effects of zinc on different leukocyte ...

    Authors: Hajo Haase, Dawn J. Mazzatti, Andrew White, Klaus H. Ibs, Gabriela Engelhardt, Silke Hebel, Jonathan R. Powell and Lothar Rink
    Citation: Molecular Medicine 2007 13:130070362
    Content type: Proceedings Published on:

  28. Overactivation of glutamate receptors and subsequent deregulation of the intraneuronal calcium ([Ca2+]i) levels are critical components of the injurious pathways initiated by cerebral ischemia. Another hallmark o...

    Authors: Valerio Frazzini, Ilario G. Rapposelli, Carlo Corona, Erica Rockabrand, Lorella M. T. Canzoniero and Stefano L. Sensi
    Citation: Molecular Medicine 2007 13:130070356
    Content type: Proceedings Published on:

  29. Zinc translocation from presynaptic nerve terminals to postsynaptic neurons has generally been considered the critical step leading to the accumulation of intracellular free zinc and subsequent neuronal injury...

    Authors: Yumin Zhang, Elias Aizenman, Donald B. DeFranco and Paul A. Rosenberg
    Citation: Molecular Medicine 2007 13:130070350
    Content type: Proceedings Published on:

  30. Several processes by which astrocytes protect neurons during ischemia are now well established. However, less is known about how neurons themselves may influence these processes. Neurons release zinc (Zn2+) from ...

    Authors: Sang Won Suh, Koji Aoyama, Conrad C. Alano, Christopher M. Anderson, Aaron M. Hamby and Raymond A. Swanson
    Citation: Molecular Medicine 2007 13:130070344
    Content type: Proceedings Published on:

  31. Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian proteins and can modulate the function of many others. Because of the pleiotropic effects of zinc on every aspect of...

    Authors: Israel Sekler, Stefano L. Sensi, Michal Hershfinkel and William F. Silverman
    Citation: Molecular Medicine 2007 13:130070337
    Content type: Proceedings Published on:

  32. Zinc is essential for cell growth. For many years it has been used to treat various epithelial disorders, ranging from wound healing to diarrhea and ulcerative colon disease. The physiological/molecular mechan...

    Authors: Michal Hershfinkel, William F. Silverman and Israel Sekler
    Citation: Molecular Medicine 2007 13:130070331
    Content type: Proceedings Published on:

  34. Non-invasive monitoring may be useful after kidney transplantation (KT), particularly for predicting acute rejection (AR). It is less clear whether chronic allograft nephropathy (CAN) is also associated with c...

    Authors: Valeria R Mas, Luciana A Mas, Kellie J Archer, Kenneth Yanek, Anne L King, Eric M Gibney, Adrian Cotterell, Robert A Fisher, Marc Posner and Daniel G Maluf
    Citation: Molecular Medicine 2007 13:1305315
    Content type: Research Article Published on:

  35. CD36 is a transmembrane glycoprotein of the class B scavenger receptor family. The CD36 gene is located on chromosome 7 q11.2 and is encoded by 15 exons. Defective CD36 is a likely candidate gene for impaired fat...

    Authors: Monika Ewa Rać, Krzysztof Safranow and Wojciech Poncyljusz
    Citation: Molecular Medicine 2007 13:1305288
    Content type: In Overview Published on:

  36. Anticancer drugs are generally plagued by toxic manifestations at doses necessary for control of various forms of cancer. Incorporating such drugs into liposomes not only reduces toxicity but also enhances the...

    Authors: Arif Khan, Aijaz A Khan, Varun Dwivedi, Manzoor G Ahmad, Seema Hakeem and Mohammad Owais
    Citation: Molecular Medicine 2007 13:1305266
    Content type: Research Article Published on:

  38. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a vascular dementing disease caused by mutations in the NOTCH3 gene, most which are missense mutations leadi...

    Authors: Saara Ihalainen, Rabah Soliymani, Erika Iivanainen, Kati Mykkänen, Annele Sainio, Minna Pöyhönen, Klaus Elenius, Hannu Järveläinen, Matti Viitanen, Hannu Kalimo and Marc Baumann
    Citation: Molecular Medicine 2007 13:1305305
    Content type: Research Article Published on:

  39. Fibroblast-like synoviocytes (FLS) isolated from joints of rheumatoid arthritis (RA) patients display proliferative and invasive properties reminiscent of those of malignant tumor cells. Rac small GTPases play...

    Authors: Amanda Chan, Mumtaz Akhtar, Max Brenner, Yi Zheng, Percio S Gulko and Marc Symons
    Citation: Molecular Medicine 2007 13:1305297
    Content type: Research Article Published on:

  40. T cells have a central role in the pathogenesis of autoimmune arthritis, and several abnormalities in T cell homeostasis have been described in rheumatoid arthritis (RA). We hypothesized that T cell phenotypes...

    Authors: Max Brenner, Teresina Laragione, Nuriza C Yarlett and Pércio S Gulko
    Citation: Molecular Medicine 2007 13:1305277
    Content type: Research Article Published on:

  42. Ligands specific to cell surface receptors have been heavily investigated in cancer research. Phage display technology is a powerful tool in this field and may impact clinical issues including functional diagn...

    Authors: Binghua Zhang, Yanqiong Zhang, Jiwei Wang, Yangde Zhang, Jiji Chen, Yifeng Pan, Lifeng Ren, Zhiyuan Hu, Jingfeng Zhao, Mingmei Liao and Shunwei Wang
    Citation: Molecular Medicine 2007 13:1305246
    Content type: Research Article Published on:

  43. Idiopathic portal hypertension (IPH) is a disorder of unknown etiology, clinically associated with portal hypertension in the absence of cirrhosis. This study was designed to delineate the characteristics of I...

    Authors: Hiroyasu Morikawa, Akihiro Tamori, Shuhei Nishiguchi, Masaru Enomoto, Daiki Habu, Norifumi Kawada and Susumu Shiomi
    Citation: Molecular Medicine 2007 13:1305240
    Content type: Research Article Published on:

  44. HIV-1 Vpr plays a pivotal role in viral pathogenesis and is preferentially targeted by the host immune system. In this report, we demonstrate that a small heat shock protein, HSP27, exhibits Vpr-specific antiv...

    Authors: Dong Liang, Zsigmond Benko, Emmanuel Agbottah, Michael Bukrinsky and Richard Y Zhao
    Citation: Molecular Medicine 2007 13:1305229
    Content type: Research Article Published on:

  45. Diets consumed in industrialized countries are rich in fat and increase the incidence of atherosclerosis, a process reported to be influenced by gender. Considering the anti-atherogenic role attributed to seru...

    Authors: Elena Thomàs-Moyà, Magdalena Gianotti, Ana M. Proenza and Isabel Lladó
    Citation: Molecular Medicine 2007 13:130030203
    Content type: Research Article Published on:

  46. Macrophage migration inhibitory factor (MIF) is a ubiquitous cytokine that functions in reproduction and plays an important role in sperm maturation and motility. Here we reveal a correlation between MIF level...

    Authors: Bayan Aljabari, Aldo E. Calogero, Anna Perdichizzi, Enzo Vicari, Raja Karaki, Tarek Lahloub, Rashed Zatari, Khaleel El-Abed, Ferdinando Nicoletti, Edmund J. Miller, Valentin A. Pavlov and Yousef Al-Abed
    Citation: Molecular Medicine 2007 13:130030199
    Content type: Research Article Published on:

  47. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in accelerated atherosclerosis in diabetes. We have recently found that the soluble form of RAGE (sRAGE) levels are signi...

    Authors: Kazuo Nakamura, Sho-ichi Yamagishi, Hisashi Adachi, Yayoi Kurita-Nakamura, Takanori Matsui, Takafumi Yoshida and Tsutomu Imaizumi
    Citation: Molecular Medicine 2007 13:130030185
    Content type: Research Article Published on:

  48. Angiomyolipomas are benign tumors of the kidney which express phenotypes of smooth muscle, fat, and melanocytes. These tumors appear with increased frequency in the autosomal dominant disorder tuberous scleros...

    Authors: So Dug Lim, William Stallcup, Benjamin Lefkove, Baskaran Govindarajan, Kit Sing Au, Hope Northrup, Deborah Lang, David E. Fisher, Avani Patel, Mahul B. Amin and Jack L. Arbiser
    Citation: Molecular Medicine 2007 13:130030160
    Content type: Research Article Published on:

  49. Phosphatase of regenerating liver-3 (PRL-3) has been proposed to promote the invasion of tumor cells to metastasis sites. However, the effect of PRL-3 on spontaneous metastasis has not been clearly demonstrate...

    Authors: Feng Qian, Yu-Pei Li, Xia Sheng, Zi-Chao Zhang, Ran Song, Wei Dong, Shao-Xian Cao, Zi-Chun Hua and Qiang Xu
    Citation: Molecular Medicine 2007 13:130030151
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2007 13:Art11

  50. Increased activation of the transcription factor NFκB in the neutrophils has been associated with the pathogenesis of sepsis, acute lung injury (ALI), bronchopulmonary dysplasia (BPD), and other neutrophil-med...

    Authors: Veronika Miskolci, Janet Rollins, Hai Yen Vu, Chandra C. Ghosh, Dennis Davidson and Ivana Vancurova
    Citation: Molecular Medicine 2007 13:130030134
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658