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Table 1 TCR J α gene segment usage by V α 2.3 + lung accumulated CD4 + BAL T cells recovered from four sarcoidosis patients (Patients 1–4) and the number of identical nucleotide α -sequences found repeatedly within individual J α segments

From: Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

Jα Segment

Patient

1

2

3

4

1.3

 

2

  

1.4

1

1

2

2

    

2 identical

1.5

2

 

1

 

1.8

 

2

3 (17%)

7 (39%)b

    

2 identical

3.1

   

1

3.2

1

  

1

4.1

2

   
 

2 identical

   

6.1

 

2

  
  

2 identical

  

9.5

 

1

  

9.7

  

3 (17%)

 
   

3 identical

 

9.11

1

9 (18%)a

1

1

  

2 identical

  

9.14

1

  

2

    

2 identical

9.15

1

2

  
  

2 identical

  

14.1

2

1

 

1

14.4

 

1

  

15.1

 

1

  

15.2

 

7 (14%)

1

 
  

6 identical

  

15.3

2

2

1

2

16.3

 

3 (6%)

1

 

16.6

3 (10%)

7 (14%)

1

 
  

6 identical

  

17.2

 

1

  

17.3

8 (26%)

3 (6%)

  
 

2 + 2 identical

2 identical

  

17.5

1

   

17.6

  

2

 

17.7

1

   

17.9

2

4 (8%)

1

 
 

2 identical

3 identical

  

17.10

3 (10%)

2

1

1

  1. Individual Jα family members used ≥3 times are marked by shadowing.
  2. a2 + 4 of the amino acid sequences were identical (see Table 2).
  3. b5 of the amino acid sequences were identical (see Table 3).
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Molecular Medicine

ISSN: 1528-3658