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Table 3 Indentical or similar TCR VJ α sequences found in V α 2.3 + J α 1.8 + lung accumulated CD4 + BAL T cells recovered from a sarcoidosis patient (Patient 4)

From: Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

Sequence Vα2.3   Jα 1.8
  C V V   R H M D S
4.3 5′-TGT GTG GTG AGA CAC ATG GAT AGC
4.12 5′-TGT GTG GTG AGG CAC ATG GAT AGC
4.20 5′-TGT GTG GTT CGC CAC ATG GAT AGC
4.14 + 4.25 5′-TGT GTG GTC CGC CAC ATG GAT AGC
  C V V   R Y M D S
4.23 5′-TGC GTG GTA CGG TAC ATG GAT AGC
  1. Nucleotides that alter between sequences are underlined. Note that the substitution of histidine (H), in the group of sequences 4.3–4.25, to a tyrosine (Y), in sequence 4.23, constitutes only a minor change in the properties of the amino acid sequence.