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Table 3 Indentical or similar TCR VJ α sequences found in V α 2.3 + J α 1.8 + lung accumulated CD4 + BAL T cells recovered from a sarcoidosis patient (Patient 4)

From: Restricted Usage of T Cell Receptor Vα/Jα Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3+ Sarcoidosis Patients

Sequence

Vα2.3

 

Jα 1.8

 

C

V

V

 

R

H

M

D

S

4.3

5′-TGT

GTG

GTG

AGA

CAC

ATG

GAT

AGC

4.12

5′-TGT

GTG

GTG

AGG

CAC

ATG

GAT

AGC

4.20

5′-TGT

GTG

GTT

CGC

CAC

ATG

GAT

AGC

4.14 + 4.25

5′-TGT

GTG

GTC

CGC

CAC

ATG

GAT

AGC

 

C

V

V

 

R

Y

M

D

S

4.23

5′-TGC

GTG

GTA

CGG

TAC

ATG

GAT

AGC

  1. Nucleotides that alter between sequences are underlined. Note that the substitution of histidine (H), in the group of sequences 4.3–4.25, to a tyrosine (Y), in sequence 4.23, constitutes only a minor change in the properties of the amino acid sequence.