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Fig. 4 | Molecular Medicine

Fig. 4

From: Hemoglobin Switching in Humans Is Accompanied by Changes in the Ratio of the Transcription Factors, GATA-1 and SP1

Fig. 4

GATA-1 and SP1 activities in erythroid cultures derived from β o -thalassemia patients

(a) Patient A has thalassemia intermedia due to elevated HbF production. (b) Patient B is the niece of Patient A. She is transfusion dependent β-thalassemia major. (c) An unrelated β-thalassemia major patient. , GATA-1 binding activity; , SP1 binding activity.

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