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Table 1 Characteristics of wild-type and mutant h-TR β 1

From: Cell Type-Dependent Modulation of the Dominant Negative Action of Human Mutant Thyroid Hormone β1 Receptors

Receptor

Codon

Amino Acid

Exon

Affinity Constant of T3 Binding (Ka × 109 M−1)

WT-TRβ1

—

—

—

1.50

ED

317

Ala→Thr

9

0.22

OK

442

Met→Val

10

0.20

PV

448

Frameshift

10

0.01

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Molecular Medicine

ISSN: 1528-3658