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Table 1 Characteristics of wild-type and mutant h-TR β 1

From: Cell Type-Dependent Modulation of the Dominant Negative Action of Human Mutant Thyroid Hormone β1 Receptors

Receptor Codon Amino Acid Exon Affinity Constant of T3 Binding (Ka × 109 M−1)
WT-TRβ1 — — — 1.50
ED 317 Ala→Thr 9 0.22
OK 442 Met→Val 10 0.20
PV 448 Frameshift 10 0.01
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Molecular Medicine

ISSN: 1528-3658