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Table 3 Summary of distribution of HLA DQB1 * 03

From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia

Patients (No.) HLA DQB1 * 03 (Positive) (%) Odds Ratio (95% CI)
CIN (178)
CIN 1 (66) CIN 3 (112)
109 (61) 37 (56) 72 (64) 3.03 (2.11–4.35)
2.45 (1.45–4.12) 3.45 (2.23–5.33)
HPV negative CIN (47) 25 (53) 2.18 (1.19–3.97)
HPV positive CIN (131) 84 (64) 3.43 (2.28–5.15)
Controls (420) (HPV negative 144 (34) 1*
  1. HLA DQB1 * 03 typing was performed on DNA from cervical smears of 178 women with CIN (CIN I = 66; CIN III = 112) and 420 healthy women who had a normal smear. All samples were successfully amplified for the locus. HPV typing was performed for types 16, 18, 31, and 33 on all the test and control samples.
  2. Of CIN cases, 61% were positive (56% of CIN 1, 64% of CIN III) for the HLA DQB1 * 03 type, compared with 34% of controls. This was significant (χ2 trend = 37.3, p < 0.001), and the odds ratio for CIN overall was 3.03 (95% CI 2.11–4.35). The association was significant for both CIN III and CIN I (odds ratio 3.45 versus 2.45), stronger for CIN HI, but not significantly different from CIN I.
  3. One hundred thirty-one patients with CIN (73.5%) were positive for one or more HPV types 16, 18, 31, and 33. Of HPV-positive CIN, 64% were of the type DQB1 * 03. There was a significant association between DQB1 * 03 and HPV (χ2 trend = 23.2, p < 0.001) with an odds ratio of 3.43 (95% CI 2.28–5.15).