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Table 5 Association between HLA DQB1 * 03 allele and CIN

From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia

HLA DQB1 * 03 Allele

CIN 3 (2n = 224)

CIN 1 (2n = 132)

Controls (2n = 840)

Odds Ratio (95% CI)

χ2 Trend

0301

49 (21)

25 (19)

79 (9)

2.53 (1.79–3.57)

28.6 (p < 0.001)

0302

45 (20)

16 (12)

85 (10)

1.84 (1.29–2.62)

15.5 (p < 0.001)

0303

5 (2)

7 (5)

21 (2.5)

1.36 (0.67–2.76)

0.05 (p = 0.82)

0304

0

0

1 (0.1)

0

 

Non-DQB1 * 03

125

84

654

1*

 

Total

224

132

840

  
  1. The ARFLP-PCR technique used on DNA from cervical smears, following Mlu I digestion, identifies women who are negative, heterozygous, or homozygous for the DQB1 * 03 locus (Fig. 2). Of women with CIN, 38% were negative, 37% were heterozygous, and 23% were homozygous for the DQB1 * 03 locus (χ2 trend = 39.01, p < 0.001). Compared with controls, the odds ratio was greater for homozygosity (4.0, 95% CI 2.43–6.6) than for heterozygosity (2.63, 95% CI 1.75–3.94). Further typing of the DQB1 * 03 locus in positive samples showed that the 0301 allele was present in 40% of CIN as opposed to 9% of controls (odds ratio 2.53, 95% CI 1.79–3.57; χ2 trend = 28.6, p <0.001). DQB1 * 0302 was present in 32% and 10% of CIN and controls, respectively (odds ratio 1.84, 95% CI 1.29–2.62).