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Table 5 Association between HLA DQB1 * 03 allele and CIN

From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia

HLA DQB1 * 03 Allele CIN 3 (2n = 224) CIN 1 (2n = 132) Controls (2n = 840) Odds Ratio (95% CI) χ2 Trend
0301 49 (21) 25 (19) 79 (9) 2.53 (1.79–3.57) 28.6 (p < 0.001)
0302 45 (20) 16 (12) 85 (10) 1.84 (1.29–2.62) 15.5 (p < 0.001)
0303 5 (2) 7 (5) 21 (2.5) 1.36 (0.67–2.76) 0.05 (p = 0.82)
0304 0 0 1 (0.1) 0  
Non-DQB1 * 03 125 84 654 1*  
Total 224 132 840   
  1. The ARFLP-PCR technique used on DNA from cervical smears, following Mlu I digestion, identifies women who are negative, heterozygous, or homozygous for the DQB1 * 03 locus (Fig. 2). Of women with CIN, 38% were negative, 37% were heterozygous, and 23% were homozygous for the DQB1 * 03 locus (χ2 trend = 39.01, p < 0.001). Compared with controls, the odds ratio was greater for homozygosity (4.0, 95% CI 2.43–6.6) than for heterozygosity (2.63, 95% CI 1.75–3.94). Further typing of the DQB1 * 03 locus in positive samples showed that the 0301 allele was present in 40% of CIN as opposed to 9% of controls (odds ratio 2.53, 95% CI 1.79–3.57; χ2 trend = 28.6, p <0.001). DQB1 * 0302 was present in 32% and 10% of CIN and controls, respectively (odds ratio 1.84, 95% CI 1.29–2.62).