HPV Type Present | Number of Patients | DQB1 * 03 (Positive) (%) | Odds Ratio (95% CI) |
|---|
16 | 75 | 45 (60) | 2.88 (1.74–4.74) |
18 | 9 | 7 (77) | 6.71 (1.56–∞) |
31 | 16 | 11 (68) | 4.22 (1.5–11.84) |
33 | 10 | 6 (60) | 2.88 (0.86–9.64) |
Multiple types | 21 | 15 (71) | 4.79 (1.88–12.2) |
Controls | 420 | 144 (34) | 1* |
(HPV negative) | | | |
- HPV typing was performed for the major oncogenic types, HPV 16, 18, 31, and 33. Of CIN cases, 57% were positive for HPV 16, 7% for HPV 18, 12% for HPV 31, and 7% for HPV 33, and 16% were positive for multiple types. All types correlated strongly with DQB1 * 03, but there was insufficient data to find differences in the strength of association between the types. The highest odds ratio was found for women with HPV 18 or multiple types. There was significant correlation with “gene dosage” at the DQB1 * 03 locus, with 39% of HPV-positive CIN being heterozygous and 24% homozygous (χ2 trend =37.9, p < 0.001). Homozygosity was significantly associated with HPV-positive CIN (odds ratio 4.47, 95% CI 2.58–7.77). Further typing of the HLA DQB1 * 03 locus in positive samples showed that the 0301 allele was most strongly associated with HPV infection (odds ratio 2.69, 95% CI 1.88–3.94; χ2 trend = 32.9, p < 0.001).
