Fig. 1From: Adenovirus-Mediated Transfer of the Herpes Simplex Virus Thymidine Kinase Gene Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation Following Balloon Angioplasty of the Rat Carotid ArteryInhibition of medial VSMC DNA synthesis by ADV-tk/+GC Rat carotid arteries were infected with 2 × 109 pfu of ADV-tk for 5 min immediately following balloon injury. Animals were treated for 3 days with systemic ganciclovir (ADV-tk/+GC) or saline (ADV-tk/ -GC) administered by intraperitoneal injection beginning 24 hr after balloon injury and adenovirus infection. Medial VSMC proliferation was measured by BrdU incorporation between 2 and 4 days after balloon injury and adenovirus infection.Back to article page