Skip to main content
Fig. 2 | Molecular Medicine

Fig. 2

From: Adenovirus-Mediated Transfer of the Herpes Simplex Virus Thymidine Kinase Gene Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation Following Balloon Angioplasty of the Rat Carotid Artery

Fig. 2

Inhibition of neointimal formation by ADV-tk/+GC following arterial injury (opposite)

Adult rats underwent carotid artery angioplasty and adenovirus-mediated gene transfer with ADV-tk or ADV-ΔE1 as described in Materials and Methods, and were then randomized to receive systemic therapy with either ganciclovir (ADV-tk/ + GC or ADV-ΔE1/ + GC) or saline (ADV-tk/-GC or ADV-ΔE1/-GC) for 6 days. Carotid arteries were obtained for analysis 20 days following arterial injury and gene transfer. Representative photomicrographs from ADV-ΔE1/-GC (A and B), ADV-ΔE1/ + GC (C and D), ADV-tk/-GC (E and F), or ADV-tk/ + GC (G and H) treated arteries are shown. (A, C, E, and G) Magnification 100×; (B, D, F, and H) 400×. Arrows delineate the internal elastic lamina. Note the significant reduction in neointima formation in the ADV-tk/ + GC artery.

Back to article page