Role of VEGF as a hypoxia-inducible mitogen
All results expressed as the mean cell number of triplicate wells ± SD. Note y-axis does not originate at zero. (a) flt-1/Fc and CD4/Fc soluble receptors (in ng/ml) were tested for the ability to neutralize VEGF (2 ng/ml) stimulated endothelial cell proliferation. (b) Growth of endothelial cells in conditioned media from normoxia and hypoxia cultured hRPE, and in conditioned media plus flt-1 /Fc or CD4/Fc soluble receptors (200 ng/ml). (c) Soluble receptor (200 ng/ml) effects on VEGF (2 ng/ml) and bFGF (1 ng/ml) stimulated growth of endothelial cells.