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Table 2 Peak LOD scores for pairwise linkage analysis between NRAMP and previously mapped (15, 20) 2q34 (TNP1) and 2q35 (IL8RB, VIL1, DES) markers calculated for 36 Brazilian families.

From: Genomic Organization and Sequence of the Human NRAMP Gene: Identification and Mapping of a Promoter Region Polymorphism

Marker Intervals

n

Peak LOD Score

RF

TNP1-NRAMP

14

10.49

0.026

TNP1-IL8RB

9

6.02

0.032

TNP1-VIL1

15

9.84

0.001

TNP1-DES

19

11.45

0.046

NRAMP-IL8RB

11

3.56

0.072

NRAMP-VIL1

15

10.94

0.001

NRAMP-DES

20

8.94

0.051

IL8RB-VIL1

10

5.80

0.065

IL8RB-DES

12

10.03

0.035

VIL1-DES

14

9.47

0.059

  1. RF = recombination fraction (M = F) at which the peak LOD score was obtained. n = number of families contributing to the analysis.
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Molecular Medicine

ISSN: 1528-3658