Fig. 1
From: Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention

Presumed interaction of anti-NLS compounds with HIV-1 MA p17 NLS
One of the anti-NLS compounds, H-0294, is shown. Reversible reaction of a carbonyl group with an amino group of any lysine (including those within the MA p17 NLS) results in the formation of a Schiff base. Formation of two Schiff bases after reaction with the adjacent lysines characteristic of nuclear localization signals would stabilize the bimolecular complex, shifting the equilibrium toward product formation.