Fig. 2
From: Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention
Dose response curves of H-0294 in human monocytes infected with HIV-1 ADA
Monocyte cultures were infected with HIV-1ADA with MOI 1 ng p24/106 cells in the presence of indicated concentrations of H-0294. After an overnight incubation, free virus was washed away, medium was changed, and incubation was continued in the presence of drug. Half the volume of culture medium was changed every 3–4 days, and samples were withdrawn for RT analysis at the same time. A representative experiment out of three performed with cells from different donors is shown. Each concentration of the drug was assayed in triplicate and presented data are means.