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Table 1 Drug effect on [ 3 H]clozapine binding in rat brain membranes

From: Clozapine: Selective Labeling of Sites Resembling 5HT6 Serotonin Receptors May Reflect Psychoactive Profile

Drug Ki (nM)
Histamine H1 Triprolidine 1,000
Adrenergic α 1 Prazosin >10,000
Muscarinic Cholinergic  
Scopolamine 0.8
Atropine 1.0
Butyrophenones Pipamperone 400
Spiperone 30
Phenothiazines Fluphenazine 20
Trifluoperazine 30
Thioridazine 30
Chlorpromazine 20
Tricyclic Antidepressants Nortriptyline 30
Imipramine 150
Amitriptyline 30
Ergot Alkaloids Ergotamine 10
Dihydroergotamine 20
  1. Increasing concentrations of the indicated compounds were used to inhibit the binding of 1 nM [3H]clozapine to rat brain membranes. Ki values were determined from the IC50’s by the method of Cheng and Prusoff (15). Results are the means of at least two experiments run in duplicate.