Light microscopy micrographs showing eosin/hematoxylin (a–d) and oil-red-O (e–h) staining of aortic sections from euglycemic rabbits treated with AGE-modified rabbit serum albumin (AGE-RSA) or saline with varying diet.
Treatments of rabbits were as follows: (a,e) AGE-RSA, 16 mg/kg/d i.v. × 4 months; (b,f) normal saline, 0.5 ml/day, i.v. × 4 months; (c,g) AGE-RSA, 16 mg/Kg/d i.v. × 4 months plus 2% cholesterol-rich diet (CRD) × 2 weeks (AGE + CRD); (d,h) CRD alone × 2 weeks. (H&E; 200×.)