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Table 1 Rabbit plasma cholesterol levels during administration of AGE-RSAa and CRDb

From: Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

Group Treatment Baseline 14 Weeks 16 Weeks
Control (normal saline) 56 ± 22 67 ± 12 68 ± 24
AGE-RSA 62 ± 28 87 ± 22 78 ± 16
AGE-RSA + CRDb 73 ± 16 53 ± 18 1380 ± 322c
CRD* 50 ± 2 72 ± 30 966 ± 238c
  1. Data are expressed in mg/dl (mean ± SD, n = 5/group).
  2. aAGE-RSA was infused at 16 mg/kg/day i.v. for 16 weeks.
  3. bCRD, cholesterol-rich diet (2% USP cholesterol + 10% corn-oil) was introduced at last 2 weeks of study.
  4. cStatistically different from control (p < 0.001) and from AGE-RSA group (p < 0.002).