Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

Table 1 Rabbit plasma cholesterol levels during administration of AGE-RSA^a and CRD^b

Group Treatment	Baseline	14 Weeks	16 Weeks
Control (normal saline)	56 ± 22	67 ± 12	68 ± 24
AGE-RSA	62 ± 28	87 ± 22	78 ± 16
AGE-RSA + CRD^b	73 ± 16	53 ± 18	1380 ± 322^c
CRD*	50 ± 2	72 ± 30	966 ± 238^c

Data are expressed in mg/dl (mean ± SD, n = 5/group).
^aAGE-RSA was infused at 16 mg/kg/day i.v. for 16 weeks.
^bCRD, cholesterol-rich diet (2% USP cholesterol + 10% corn-oil) was introduced at last 2 weeks of study.
^cStatistically different from control (p < 0.001) and from AGE-RSA group (p < 0.002).

ISSN: 1528-3658