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Table 1 Rabbit plasma cholesterol levels during administration of AGE-RSAa and CRDb

From: Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

Group Treatment

Baseline

14 Weeks

16 Weeks

Control (normal saline)

56 ± 22

67 ± 12

68 ± 24

AGE-RSA

62 ± 28

87 ± 22

78 ± 16

AGE-RSA + CRDb

73 ± 16

53 ± 18

1380 ± 322c

CRD*

50 ± 2

72 ± 30

966 ± 238c

  1. Data are expressed in mg/dl (mean ± SD, n = 5/group).
  2. aAGE-RSA was infused at 16 mg/kg/day i.v. for 16 weeks.
  3. bCRD, cholesterol-rich diet (2% USP cholesterol + 10% corn-oil) was introduced at last 2 weeks of study.
  4. cStatistically different from control (p < 0.001) and from AGE-RSA group (p < 0.002).