expression in the human fetal kidney and in murine embryogenesis
(A and B) Expression of VHL in the human fetal kidney at 14 weeks gestation shown in toluidene blue O-stained brightfield photomicrographs and the corresponding darkfield images. VHL expression is evident in the proximal tubules (pt), distal tubules (dt), and metanephric blastema (mb) (A, B: ×60), however, a prominent difference is noted in proximal tubular expression when compared with the other structures. (C, D, E, and F) Expression of VHL in murine embryogenesis (E = 13.5 days). Light and corresponding darkfield photomicrographs of thorax and abdominal development revealing expression of VHL in the atrium (a) and ventricle (v) of the heart. Expression is more prominent in the developing liver (li), pancreas (p), brachial arch (ba), and the urogenital ridge (ur) and cephalad, the adjacent neuroepithelium (ne) lining the developing brain structures (C, D: ×60; E, F: ×60). (G, H, I, and J) Higher magnification views of light and corresponding darkfield photomicrographs of murine VHL expression in the abdomen (E = 13.5 days) showing moderate expression in the intestines (in), and more intense expression in the developing urogenital ridge (ur), gonad (gd), and mesonephric tubules (mt). The kidney (k) and pancreas (p) show high levels of VHL expression with lower levels of expression in the adjacent adrenal gland (ad), vertebral body (vb), ganglion (gl), and pelvic organs of the uterus (ut), bladder (bl), and rectum (r) (G, H: ×120; I, J: ×50).