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Table 2 V H and V κ region gene sequence analysis of 10 Burkitt’s lymphoma cell lines

From: Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

Burkitt Line

Class

Origina

VH Family

VHb Gene

Mutations/bp Sequencedc

% Mutation

Vκ Family

Vκb Gene

Mutations/bp Sequencedc

% Mutation

Jijoye P79d

μ

e

    

3

L2

15/292

5.1

Daudid

μ

e

3

H11

52/337

15.0

1

02

29/288

10.1

BL36d

γ

s

3

DP58

19/337

5.6

3

L2

5/297

1.7

BL29d

μ

s

4

VH4.21

2/332

0.6

4

B3

10/294

3.4

   

2

S12-9e

18/347

5.2

    

JId

μ

s

3

LSG10.1

8/343

2.3

4

B3

4/294

1.4

BL41

μ

s

3

1-9III

14/338

4.1

3

A27f

13/294

4.4

       

4

B3

0/286

0.0

CA46

μ

s

5

BLK

1/333

0.3

3

A27

3/297

1.0

ST486

μ

s

3

1-9III

13/326

4.0

2

A3

4/295

1.4

CW698

μ

s

3

DP51

15/341g

4.4

1

02

6/299

2.0

BL31

μ

s

4

VH4.21

14/327

4.3

2

A3

2/297

0.7

  1. aThe origin of the lines is indicated (e, endemic; s, sporadic).
  2. bReferences for VH germline genes: DP51, DP58 (34), H11 (35), VH4.21, BLK (36), S12-9 (37), LSG10.1 (38), 1–9III (39). References for Vκ germline genes are summarized by Schäble & Zachau (31).
  3. cThe number of basepairs sequenced represents the sum of the V and J segments, excluding DH genes and N nucleotides.
  4. dEBV positive lines.
  5. edeletion of eight nucleotides in FRI.
  6. fdeletion of three nucleotides in CDRI.
  7. ginsertion of three nucleotides in CDRII.
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Molecular Medicine

ISSN: 1528-3658