Fig. 11From: Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway Taxol-induced prophase-blocked wt p53 and p53-null MEFs both exhibit signs of apoptosis wt-expressing MEFs (A, B, C, and D) and p53-null MEFs (E and F) were treated with 0 (A and B) or 1 µM taxol (C–F) for 8 hr prior to fixation and processing for TUNEL (B, D, and F) and counterstained with DAPI (A, C, and E). Arrow in Panels A and B indicates a control cell in metaphase. Bar in Panel F represents 10 µm; magnification is the same for all panels.Back to article page