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Fig. 7 | Molecular Medicine

Fig. 7

From: Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

Fig. 7

Comparison of wt p53-expressing MEFs with p53-null MEFs response to taxol.

(A) wt p53 and (B) p53-null MEFs treated with 1 µM (◇), 250 nM (○), or 100 nM (△) taxol and scored at the indicated times for percentage of cells in prophase (solid lines) and multimininucleation (dotted lines). (C) a comparison of viable cells in M (adherent cells) wt p53 (solid lines) or p53-null MEFs (dotted lines). Taxol concentrations 1 µM (□) and 250 nM (○) are shown.

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