Table 2 Comparison of EC 50 values for taxol-induced mitotic effects and cytotoxicity between ±p53 MEF phenotypes
From: Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway
Cell Type | Mitotic Arresta (nM) | Aberrant Mitosisa (nM) | Cytotoxicityb (nM) |
|---|---|---|---|
wt p53 MEF | 135.6 ± 9.6 | 46.2 ± 5.3 | 95.4 ± 32 |
p53 −/− MEF | 120.0 ± 6.1 | 47.2 ± 0.1 | 110.7 ± 17.4 |