Immunolabeling of untreated transgenic and nontransgenic mice
(A) Immunolabeling of β and δ cell with antiserum against mouse IAPP. This pattern occurs in both transgenic and nontransgenic mice. Antiserum A110 1:200; 10 nm gold particles; bar = 500 nm. (B) Immunolabeling of β cells in a transgenic mouse with a human specific antiserum. No labeling occurs on the δ cell in the center of the figure. Antiserum A133 1:200; 10 nm gold particles; bar = 200 nm. (C) Immunolabeling of a δ cell with antiserum against somatostatin (1: 1000); 10 nm gold particles; bar = 200.