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Table 1 Blood glucose concentration mg/100 m (mean ± SEM) in hIAPP transgenic and nontransgenic litter mates, before and during long-term treatment with glucocorticosteroid

From: Amyloid Formation in Response to β Cell Stress Occurs In Vitro, but Not In Vivo, in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide

Day

Transgenic Mice

Nontransgenic Mice

Fasting

  

0

67.1

73.6

 

2.4

4.1

 

n = 11

n = 10

Fed

  

0

117.2

126.8

 

5.2

4.5

 

n = 11

n = 10

60

206.4a

214.8a

 

4.5

3.1

 

n = 11

n = 10

130

214.5b

217.3b

 

3.4

3.8

 

n = 8

n = 7

170

219.6b

222.1

 

3.6

4.7

 

n = 8

n = 7

185

220.0

221.8

 

6.0

10.8

 

n = 4

n = 4

  1. ap < 0.001 versus Day 0
  2. bp < 0.05 versus Day 60.