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Fig. 2 | Molecular Medicine

Fig. 2

From: Ciliary Neurotrophic Factor Inhibits Brain and Peripheral Tumor Necrosis Factor Production and, When Coadministered with Its Soluble Receptor, Protects Mice From Lipopolysaccharide Toxicity

Fig. 2

CNTF inhibits serum TNF induction by a lethal dose of LPS

Mice were treated with LPS (30 mg/kg i.p.) with or without CNTF and sCNTFRα (10 µg/mouse and 20 µg/mouse, respectively, i.v. 30 min before LPS). Serum TNF levels were measured 1.5 and 3 hr later. Data (mean ± SE, n = 5) from two experiments are reported and TNF levels are expressed as percentage of LPS alone (100% was 4.0 ± 2.0 ng/ml at 1.5 hr and 0.27 ± 0.08 ng/ml at 3 hr). No TNF was detected in mice treated with saline or CNTF alone (not shown).

*p < 0.05 versus respective control (LPS alone) by Dunnett’s test.

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