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Table 1 Effect of CNTF on LPS-induced CS and SAA

From: Ciliary Neurotrophic Factor Inhibits Brain and Peripheral Tumor Necrosis Factor Production and, When Coadministered with Its Soluble Receptor, Protects Mice From Lipopolysaccharide Toxicity

Treatment

CS (ng/ml)

SAA (µg/ml)

Saline

42 ± 38

<0.06

CNTF

46 ± 11

0.6 ± 0.1

LPS

269 ± 36

3.0 ± 1.0

CNTF + LPS

315 ± 32

2.7 ± 0.8

CNTF + sCNTFRα + LPS

347 ± 56a

4.5 ± 0.9

  1. Mice were treated with LPS (80 µg/kg, i.V.), sCNTFRα (20 µg/mouse i.v., along with CNTF) and CNTF (10 µg/mouse i.v., simultaneously with LPS). CS was measured 2 hr and SAA 24 hr after treatment. Data are mean ± SD (five mice/group) from a representative experiment.
  2. ap < 0.01 versus LPS alone by Duncan’s test.
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Molecular Medicine

ISSN: 1528-3658