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Table 1 Clinical parameters of at-risk subjects

From: Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

Subject # Age Years Follow-Up HLA ICAa IAAb GAD Abc FPIRd
A B DR DQ
1 14 1.6 1 8 3 2 160,69,56 4,30,×20   118,155
2 23 4.8 2 44,55 3,4 5,8 55,37,14,6,5,5 ×25,9,41,×2,0,44 278,602 124,113,57
3 22 6.8 2,28 7,8 3,4 2,8 37,37,37,37,52,30, 58,46,26 8,9,2,31,7,9,×41,×1,64 1637,2259,634,1535 183,155,140,161,56
4 13 1.3 1,11 8,27 3,4 2,8 160,190 84,280   79,91
5 25 5.5 2 44,62 4,11 7,8 0,19,18,16,22,0,0 45,31,42,60,29,130,30 736,936,1336,790,810 137,143,68,15
6 20 5.5 1,2 8,62 3,4 2,8 19,19,104,86,8 480,560,400,130,300 937,2258,2389 105,238,165,128
7 18 1.7 1,3 8,18 3 2 69,69 13,20   44,47
8 9 3.2 1,2 8,44 3,4 2,8 160,160,160,160 ×2,×26,36,59 2300,1830 118,129,87
9 10 2.8 1,2 8,27 3,4 2,8 160,160,120,24 2,29,14,120 1525,1388 26,56,29
10 14 4.8 1,32 8,14 4,7 2,8 14,13,51,18 240,490,470,1000 432 318,181,165
  1. aICA, Islet cell antibody titres (JDF units).
  2. bIAA, Insulin autoantibody titres (nU insulin bound/ml serum).
  3. cGAD Ab, Glutamic acid decarboxylase autoantibody titres (nU/ml).
  4. dFPIR, First phase insulin release (sum of serum insulin concentrations at 1 and 3 min following completion of glucose injection).