TABLE 2 T cell responses of at-risk and control subject pairs to proinsulin and GAD peptides
Delta Scoresa | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pair # | Autologous | Proinsulin 10 µg/ml | Proinsulin 2 µg/ml | Proinsulin 0.4 µg/ml | GAD 10 µg/ml | GAD 2 µg/ml | GAD 0.4 µg/ml | |||||||
At-Risk | Control | At-Risk | Control | At-Risk | Control | At-Risk | Control | At-Risk | Control | At-Risk | Control | At-Risk | Control | |
1 | 881 | 2979 | 1391 | 0 | 459 | 0 | 1040 | 0 | 579 | 0 | 516 | 0 | 768 | 0 |
2 | 236 | 389 | 351 | 0 | 0 | 0 | 33 | 0 | 3263 | 0 | 190 | 0 | 199 | 0 |
3 | 6515 | 217 | 0 | 64 | 355 | 43 | 0 | 0 | 0 | 77 | 0 | 5 | 0 | 25 |
4 | 595 | 1347 | 104 | 0 | 0 | 0 | 288 | 0 | 0 | 0 | 10 | 0 | 0 | 0 |
5 | 1745 | 1269 | 694 | 0 | 0 | 0 | 0 | 0 | 1275 | 20 | 394 | 120 | 53 | 30 |
6 | 1007 | 265 | 397 | 98 | 65 | 380 | 0 | 0 | 1679 | 992 | 220 | 216 | 77 | 195 |
7 | 1392 | 454 | 467 | 93 | 0 | 0 | 0 | 0 | 2313 | 1365 | 0 | 0 | 0 | 70 |
8 | 9993 | 308 | 2128 | 0 | 1367 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
9 | 598 | 135 | 0 | 0 | 265 | 13 | 0 | 0 | 1251 | 337 | 0 | 0 | 255 | 21 |
10 | 597 | 870 | 56 | 21 | 0 | 22 | 0 | 0 | 65 | 391 | 0 | 1441 | 0 | 0 |
Mean | 2355.8 | 823.4 | 558.7 | 27.6 | 251.1 | 45.8 | 136.0 | 0 | 1042.4 | 318.1 | 133.0 | 178.2 | 135.3 | 34.1 |
Standard Error | 1025.7 | 276.2 | 219.5 | 13.0 | 135.3 | 37.4 | 104.4 | 0 | 357.1 | 153.0 | 60.5 | 142.2 | 76.0 | 19.2 |
Wilcoxon p-Value (One-Tailed) | 0.008 | 0.125 | 0.054 | 0.018 | 0.199 | 0.199 | ||||||||