Skip to main content

TABLE 2 T cell responses of at-risk and control subject pairs to proinsulin and GAD peptides

From: Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

Delta Scoresa
Pair # Autologous Proinsulin 10 µg/ml Proinsulin 2 µg/ml Proinsulin 0.4 µg/ml GAD 10 µg/ml GAD 2 µg/ml GAD 0.4 µg/ml
At-Risk Control At-Risk Control At-Risk Control At-Risk Control At-Risk Control At-Risk Control At-Risk Control
1 881 2979 1391 0 459 0 1040 0 579 0 516 0 768 0
2 236 389 351 0 0 0 33 0 3263 0 190 0 199 0
3 6515 217 0 64 355 43 0 0 0 77 0 5 0 25
4 595 1347 104 0 0 0 288 0 0 0 10 0 0 0
5 1745 1269 694 0 0 0 0 0 1275 20 394 120 53 30
6 1007 265 397 98 65 380 0 0 1679 992 220 216 77 195
7 1392 454 467 93 0 0 0 0 2313 1365 0 0 0 70
8 9993 308 2128 0 1367 0 0 0 0 0 0 0 0 0
9 598 135 0 0 265 13 0 0 1251 337 0 0 255 21
10 597 870 56 21 0 22 0 0 65 391 0 1441 0 0
Mean 2355.8 823.4 558.7 27.6 251.1 45.8 136.0 0 1042.4 318.1 133.0 178.2 135.3 34.1
Standard Error 1025.7 276.2 219.5 13.0 135.3 37.4 104.4 0 357.1 153.0 60.5 142.2 76.0 19.2
Wilcoxon p-Value (One-Tailed)   0.008   0.125   0.054   0.018   0.199   0.199
  1. aDelta Score, Mean of six replicate wells minus mean of 12 autologous wells (if less than 0, shown as 0).