Prevention of Tumor Formation in a Mouse Model of Burkitt’s Lymphoma by 6 Weeks of Treatment with Anti-c-myc DNA Phosphorothioate

Table 1 Major plasma physiological values of E µ-myc transgenic mice treated with DNA phosphorothioates for 4 to 6 weeks at doses up to 70 mg/kg/day

Treatment Group	AST (SGOT) (IU/l)	ALT (SGPT) (IU/l)	Blood Urea Nitrogen (mg/dl)	Blood Creatinine (mg/dl)	Blood Glucose (mg/dl)	Blood Sodium (mEq/dl)
Normal control^a	438 ± 241	455 ± 247	28 ± 14	0.28 ± 0.15	202 ± 15	136 ± 3^h
	(4)	(4)	(4)	(4)	(4)	(4)
Saline only	518 ± 328	131 ± 120	31 ± 12	0.29 ± 0.06	144 ± 33	154 ± 14*
	(8)	(8)	(7)	(8)	(3)	(7)
Scrambled	658 ± 341	154 ± 72	35 ± 14	0.35 ± 0.10	157 ± 47	148 ± 11
DNA antisense	(4)	(4)	(4)	(4)	(2)	(2)
	627 ± 306	88 ± 10	38 ± 24	0.43 ± 0.39	229 ± 30	145 ± 0
DNA ANOVA^c	(4)	(4)	(4)	(4)	(3)	(3)
	No	No	No	No	No	Yes

Numbers in parentheses indicate the number of samples for each measurement.
^aEµ-myc negative mice.
^bSignificant difference between these two groups by Dunn’s multiple pairwise comparison method.
^conparametric comparison among groups by Kruskal-Wallis one-way analysis of variance on ranks.

ISSN: 1528-3658