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Fig. 1 | Molecular Medicine

Fig. 1

From: δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

Fig. 1

Analyses of one- and two-site binding models for H-Dmt-Tic-OH and H-Dmt-Tic-Ala-OH to δ receptors from rat brain membranes

The solid line depicts a one-site binding model while the dashed line is a two-site model determined using Prism™. The open circles represent the mean values and error bars are the standard error of the mean (SEM) for n = 6 experiments; their absence indicates that the SEM falls within the point defined by the circle. The goodness-of-fit of H-Dmt-Tic-NH2 was essentially identical to that of H-Dmt-Tic-OH, while those for H-Dmt-Tic-ol and H-Dmt-Tic-Ala-NH2 were similar to that of H-Dmt-Tic-Ala-OH (c.f., Table 3 for actual values).

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