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Table 2 Peptides known to bind I-A u aligned to emphasize a common motif postulated to be important in binding

From: Quantitative Analysis of Peptides from Myelin Basic Protein Binding to the MHC Class II Protein, I-Au, Which Confers Susceptibility to Experimental Allergic Encephalomyelitis

  

I-A u IC 50 (nM)

MBP Ac 9–20

AcRHGSKYLATAST

20

Ovalbumin 323–339

QAVHAAHAEINEAGR

25

MBP 11–23

SKYLATASTMDHA

80

RDP-1

QVVALKPAIAAAA

100

MBP Ac 1–11

AcASQKRPSQRHG

>100,000

MBP Ac 1–11 A4

AcASQARPSQRHG

2,500

MBP Ac 1–11 Y4

AcASQYRPSQRHG

70

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Molecular Medicine

ISSN: 1528-3658