Fig. 2

Effect of near-lethal dose of endotoxin on plasma levels of PTHrP

At times indicated, blood was drawn from the inferior vena cava of anesthetized rats treated with LPS as in Fig. 1. Plasma PTHrP was measured by immunoradiometric assay utilizing antibodies directed against PTHrP (1–40) and PTHrP (60–72) (Nichols). Results (mean ± SEM; n = 3–7/group) are representative of three experiments. Differences are statistical significant by ANOVA; p values determined by two-tailed Student’s t test. *p < 0.05 (versus t = 0); **p < 0.001.