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Fig. 3 | Molecular Medicine

Fig. 3

From: Inhibition of Hemozoin Formation in Plasmodium falciparum Trophozoite Extracts by Heme Analogs: Possible Implication in the Resistance to Malaria Conferred by the β-Thalassemia Trait

Fig. 3

Inhibition of heme polymerization by ZnPP in trophozoite extracts from chloroquine-resistant and -sensitive strains

Data are expressed as the percentage of polymerization activity compared with drug-free controls. The IC50 for the chloroquine-sensitive strain is 698 ± 83 µM, and 604 ± 74 µM for the chloroquine-resistant strain. Chloroquine-resistant data is shown as closed circles, chloroquine-sensitive as closed squares. The lines represent the nonlinear least squares fit to the data of a representative experiment.

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