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Table 1 Inhibition of in vitro parasite growth by porphyrins

From: Inhibition of Hemozoin Formation in Plasmodium falciparum Trophozoite Extracts by Heme Analogs: Possible Implication in the Resistance to Malaria Conferred by the β-Thalassemia Trait

Compound

Solvent

No Inhibition at:

Zinc deuteroporphyrin bisglycol

2 mM NaOH/2% EtOH

≤104.8 µM

Zinc deuteroporphyrin bisglycol

0.02% ethanolamine

≤69.4 µM

Zinc protoporphyrin IX

2 mM NaOH/2% EtOH

≤2.6 µM

Zinc protoporphyrin IX

0.02% ethanolamine

≤5.2 µM

Coproporphyrin III

2 mM NaOH/2% EtOH

≤134.4 µM

Coproporphyrin III

0.02% ethanolamine

≤165.0 µM

Protoporphyrin IX

2 mM NaOH/2% EtOH

≤0.8 µM

Uroporphyrin III

2 mM NaOH/2% EtOH

≤157.0 µM