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Fig. 3 | Molecular Medicine

Fig. 3

From: Correction or Transfer of Immunodeficiency Due to TNF-LTα Deletion by Bone Marrow Transplantation

Fig. 3

Reconstitution of splenic structure (A) and of mucosal IgA-producing plasma cells (B) after wild-type bone marrow transplantation in TNF-LT α knock-out mice

(A) Distinct separation of T and B cell areas and germinal center formation after transplantation of wild-type bone marrow cells (2 × 106 cells) into irradiated TNF-LTα knock-out recipient mice. Clearly demarcated B220-positive B cell follicles (a) and CD3-positive T cell areas (b). By contrast, wild-type mice transplanted with mutant bone marrow cells show little distinction between splenic T and B cell areas, as B220-positive B cells (c) and CD3-positive T cells (d) are interdispersed. (B) Repopulation of the lamina propria of the ileum with IgA-producing plasma cells. While TNF-LTα knock-out mice have no IgA producing plasma cells in the lamina propria (a), TNF-LTα knock-out mice reconstituted with wild-type bone marrow cells have a repopulation with IgA-producing cells (b) resembling the wild-type control mice (c).

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