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Table 3 Showing the large proportion of alkaptonurics who are the offspring of marriage of first cousins

From: The Incidence of Alkaptonuria: A study in Chemical Individuality

No.

Total Number of Family

Number of Known Alkaptonuric Members

Observers

A. Families the Offspring of Marriages of First Cousins

1

14

4

Pavy

2

4

3

R. Kirk

3

5

2

A. E. Garrod

4

1

1

Erich Meyer

5

8

1

H. Ogden

6

4

1

Hammarsten

Total

36

12

B. Families Whose Parents Were Not Related and Not Alkaptonuric

1

3

2

Armstrong, Walter Smith, and Garrod

2

2

1

Ewald Stier

3

10

1

Noccioli and Domenici

 

7

2

Marshall and Futcher

Total

6

C. Family in Which Alkaptonuria Was Directly Inherited from a Parent

 

?

1

Osler and Futcher

Total

1

  1. aB 4 and C 1 refer to two generations of one family. No information is forthcoming as to the absence of alkaptonuria in previous generations. Ebstein and Müller’s case, which is not included in the table for reasons given above, would raise the number of families in list B to 5.