Fig. 4
From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury
Intrarenal lesions induced by GM-CSF are more rapid than CSF-1 in MRL- lpr mice
GM-CSF caused a substantial accumulation of cells extending from the subcapsule into the cortex in MRL-lpr kidneys by 8 days post-Ix (A, arrows), and more extensively by 15 days (B, arrows). In contrast, CSF-1 did not cause an accumulation of cells at 8 days (C), and the numbers of cells accumulated in the renal cortex, although evident by 15 days (D, arrows), were not as great as for GM-CSF. sc, subcapsular space. (Hematoxylin and eosin; magnification: A, B, and D, 300×; C, 500×.)