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Table 1 Genetically modified TEC constitutively secrete CSF-1 and GM-CSF, and retain the ability to secrete each cytokine for at least 4 months

From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

Culture Period

CSF-1 (CFU)

GM-CSF (CFU)

Uninf. (CFU)

1 week

56

41

0

1 month

66

46

4

4 months

51

50

3

6 months

73

8 months

42

10 months

23

  1. TEC were derived from C3H-++ mice. CSF-1 and GM-CSF were measured by colony-stimulating assay as CFU per 105 bone marrow cells. Positive standard for the assay is MRL-lpr sera at 6 months of age, 53 ° 4 CFU. Culture period, period after retroviral infection; Uninf., retroviral uninfected TEC. Culture supernatants (1 ml/5 × 105 TEC) were collected 6 days after passage. All values are means of duplicate samples.