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Table 3 Retrovirally infected CSF-1-TEC and GM-CSF-TEC implanted under renal capsule increase cytokine in the circulation

From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

Recipient (Strain)

TEC

Serum CSF-1, GM-CSF (CFU)

Pre-Ix

Post-Ix

7 days

14 days

28 days

C3H-++

CSF-1

0 ° 0

—

—

12 ° 6a (0)b

 

Uninf.

0 ° 0

0 ° 0

0 ° 0

0 ° 0

C3H-lpr

CSF-1

0 ° 0

7 ° 2a

—

14 ° 3a (0)

MRL-lpr

CSF-1

4 ° 0 (1)

10 ° 3a

13 ° 1a

25 ° 5a (0)

 

GM-CSF

0 ° 0 (0)

13 ° 5a (1)

8 ° 4a (1)

15 ° 10a (3)

 

Uninf.

4 ° 0 (1)

3 ° 1

2 ° 2

5 ° 2 (0)

  1. Recipient mice are 4–8 weeks of age. n = 3–4 in each group. Number of implanted cells: 1 × 106/mouse. CSF-1 and GM-CSF were measured by colony stimulating assay as CFU per 105 bone marrow cells. Positive standard for the assay was MRL-lpr sera at 6 months of age, 53 ° 4 CFU. Ix, implantation; Uninf.; retroviral uninfected TEC.
  2. ap < 0.05 versus pre-Ix value.
  3. bNeutralized by anti-CSF-1 or GM-CSF Ab.
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Molecular Medicine

ISSN: 1528-3658