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Table 4 CSF-1-TEC or GM-CSF-TEC cause cells to accumulate in mice with the lpr mutation

From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury

TEC

Recipient

CSF-1

GM-CSF

Uninf.

A. Subcapsular a

    

C3H-++

C3H-++

16 ° 3

16 ° 4

12 ° 1

 

C3H-lpr

28 ° 7b,c

33 ° 3b,c

12 ° 1

MRL-lpr

MRL-++

12 ° 3

15 ° 2

14 ° 1

 

MRL-lpr

39 ° 7b,d,e

57 ° 7b,d,e

12 ° 2

MRL-++

MRL-lpr

—

47 ° 8b,e

14 ° 2

B. Intrarenal a

    

C3H-++

C3H-++

2 ° 1

3 ° 1

2 ° 1

 

C3H-lpr

16 ° 3b,c

32 ° 2b,c,f

2 ° 1

MRL-lpr

MRL-++

2 ° 1

3 ° 1

2 ° 1

 

MRL-lpr

19 ° 4b,d

49 ° 6b,d,f

2 ° 1

MRL-++

MRL-lpr

—

42 ° 7b

2 ° 1

  1. aSubcapsular and intrarenal cell accumulation was evaluated by counting the numbers of cell layers in an area with the greatest lesion. Histological evaluation; 28 days post-Ix. Recipient mice: 6–8 weeks of age. n = 3–5 in each group. Number of implanted cells: 5 × 106/mouse. Uninf., retroviral uninfected TEC.
  2. bp < 0.05 versus Uninf.
  3. cp < 0.05 versus C3H-++ recipient.
  4. dp < 0.05 versus MRL-++ recipient.
  5. ep < 0.05 versus C3H-lpr recipient.
  6. fp < 0.05 versus CSF-1.
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Molecular Medicine

ISSN: 1528-3658