Table 8 CSF-1 induces an initial accumulation of Mϕ (3–7 days), followed by lymphocytes (14–28 days) in the MRL- lpr kidney
From: Macrophage Growth Factors Introduced into the Kidney Initiate Renal Injury
Cell | % | Post-Ix | |||
|---|---|---|---|---|---|
3 Days | 7 Days | 14 Days | 28 Days | ||
A. Subcapsular | |||||
Ix-TEC | β-gal | 30 | 20 | 10 | 5 |
Mϕ | F4/80 | 60 | 50 | 20 | 10 |
Lymphocytes | B220 | <5 | 20 | 30 | 40 |
CD4 | <5 | 5 | 30 | 40 | |
CD8 | 0 | 5 | <5 | <5 | |
B. Intrarenal | |||||
Mϕ | F4/80 | — | 70 | 50 | 10 |
Lymphocytes | B220 | — | 10 | 20 | 40 |
CD4 | — | 10 | 20 | 40 | |
CD8 | — | 10 | <5 | <5 | |