Time course of LPS-induced bronchoconstriction (A) and TX release into the perfusate (B)
10 min before injection of LPS (50 µg/ml), lungs were pretreated with either 0.3 µM actinoymcin D (AcD) or with 100 µM cycloheximide (Chx). Data are expressed as means ± SEM; n = 3. R/Ro′, resistance normalized to time point 0. Please note that in these experiments lungs from male Sprague-Dawley rats were used.