Time course of 5 nmol PAF-induced bronchoconstriction (A) and TX release (B)
Ten minutes before administration of PAF, lungs were pretreated with 275 µ acetyl salicylic acid (△; n = 3) or 1 juM CGP28238 (◯; n = 3; given also 30 min before PAF). Five nanomoles PAF (□; Panel A: n = 8, Panel B: n = 3). Data are means ± SEM. R/Ro, resistance normalized to time point 0.