Fig. 3
From: Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
Transgenic mouse hearts exhibit histopathologic features of HCM
Paraffin sections of hearts from control (A and C) and transgenic (B and D) mice were stained with Masson’s trichrome (A and B) or hemotoxylin/eosin (C and D). Evidence of hypertrophic cardiomyopathy was seen in the left ventricle and included focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation. The specimens shown were derived from the 143 (B) and 140 (D) mouse lines.
Many of the transgenic hearts examined also showed evidence of small vessel coronary disease (C and D). Histopathologically, this is seen as a thickening of the smooth muscle layer of the small coronary vessels (see arrows, D; L, lumen). Bar equals 0.1 mm (A, B) or 0.04 mm (C, D).